apalutamide will decrease the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP2C19 inducer, with medicines that happen to be CYP2C19 substrates can lead to lower exposure to those medications.C: Use with caution if Rewards outweigh thre